Deep Brain Stimulation for Parkinson’s Disease

By Helen Cowan

Electrical impulses may help benefit some patients.

Deep Brain Stimulation for Parkinson’s Disease
Illustration: iStock

Although not a cure, electrical stimulation deep within the brain can reduce some of the most disabling symptoms of Parkinson’s disease such as tremor, rigidity, stiffness and walking problems. Helen Cowan interviews consultant neurologist Dr Binith Cheeran from Oxford University about this procedure.

Q: Who could benefit from Deep Brain Stimulation (DBS)?
A: Previously, only people with more severe Parkinson’s were offered DBS. However, DBS is now being used in people who have had Parkinson’s for more than four years and have just started to experience fluctuations in the control of their symptoms despite taking medication. It is hoped that DBS will better control symptoms in these patients, enabling them to maintain friendships, social interaction, employment and activity, giving them better quality of life. DBS is also used to treat other diseases causing tremor, muscle spasms and contractions. It is being evaluated as a treatment for some forms of epilepsy and Tourette’s.

Q: What happens in the procedure?
A: Surgeons drill a small hole in the skull and carefully place specially-made wires (leads) into specific parts of the brain using a special guidance frame or robot. The leads are connected to an electrical pulse generator (similar to a pacemaker) placed under the skin over the chest. The procedure, which can last as little as three hours, is often done with the patient awake. This allows the neurologist to check that the wires are correctly placed to control symptoms without stimulating unintended parts of the brain. The ‘dose’ of electrical stimulation is programmed by a specialist to suppress symptoms of the disease.

Q: What are the risks?
A:
DBS should only be carried out by experienced teams, after careful evaluation of the risks and potential benefits. Potential risks, though rare, include bleeding in the brain, infection, and the risk that the leads delivering the therapy are not optimally placed (leading to side-effects with stimulation).

Q: What are the alternatives?
A:
If tablets are not controlling symptoms, other therapies include pumps that deliver gel or liquid medicines directly into the gut or through a needle placed just under the skin. These treatments may suit some people with Parkinson’s, but for most, DBS delivers a better quality of life. Scientists are looking into therapies such as stem cell treatments and growth factors, but these have not yet delivered the improvements that DBS can offer.

Q: What is the future for DBS?
A:
DBS is going through a phase of rapid innovation. Traditionally, the electrical currents from the leads in the brain resembled light coming from a bulb, travelling in all directions. Technology has been developed to steer the electrical current in a specific direction in the brain, away from unwanted structures and towards the target brain structure – rather like light from a torch – making it even safer. In the future, DBS systems will be able to automatically adjust the dose of stimulation to symptom severity, crucial in a disease that varies in severity from day to day like Parkinson’s. Some DBS systems being implanted today are already equipped to respond to measurements from devices such as an Apple Watch, and such technology should be available in clinical trials within a year.

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